The Brazilian, 20, went off in tears after appearing to injure a knee during the first half at Selhurst Park.
Palace battled admirably against a star-filled side averaging almost three goals a game and had to overcome its own injury loss - Palace captain Scott Dann also left the match on a stretcher after an earlier foul on De Bruyne - as well as City's sustained second-half pressure.
Yet the leaders turned in one of their sloppiest displays of the season - even De Bruyne's imperious passing radar was off - and needed a penalty save from Ederson Moraes off Luka Milivojevic in injury time to preserve their undefeated start.
"Before the game we would have been jumping through hoops at having claimed a point, then you get a penalty late in the game, so there is an element of sadness at a chance missed".
Sergio Aguero will comeback into the side to replace Jesus and Sterling will look to continue his strong goal scoring form as the Citizens take on a struggling Watford team.
Manchester City now sit 14 points clear at the top of the league. Maybe Arsene (Wenger) is anxious about that but I tell him many times that 2004 run is for him. "Referees have to protect the players, that is all I ask".
"We've lost Scott Dann and Jason Puncheon so I'm afraid that we've stretched our resources to the limit", he said.
Robinho joined Manchester City on a thrilling deadline day in 2008 Credit PA
When pressed on Alexis Sanchez, Guardiola added: "We will have meetings and see what is best". There is one line but where you go beyond it, that is unsafe.
The injury to Jesus could prompt City to bring forward plans to sign Alexis Sanchez from Arsenal, with the current necessity for firepower likely to outweigh the determination to wait until the summer to sign the Chilean on a free transfer. West Brom had two more days' rest than Arsenal from its last game.
Despite that, the FA feel it did not meet the criteria for a clear and obvious case of diving and the Crystal Palace player will not face any punishment.
Kyle Walker rarely let Palace's in-form Wilfried Zaha get the better of him, and made more interceptions (three), gained more possessions (13) and sprinted faster (34.69 km/h) than any other City player.
"The Premier League is a very physical league and the referees must take care of the players".
Wayne Hennessey was the first Crystal Palace goalkeeper since Nigel Martyn in May 1993 to keep a Premier League clean sheet against Man City.
United States says believes in visa crisis settlement between Ankara, Washington
The embassy stressed, however, that the Turkish government has given no assurances to Washington, refuting the USA embassy's earlier claim.