At least 10 people are feared dead and over 50 injured as two subsequent explosions hit in Parachinar in Kurram Agency.
The region has been battered by bitter sectarian violence in which Sunni militant groups have targeted Pakistan's minority Shiite Muslims in the area.
The first blast went off near a bus terminal at the market, Dawn reported, while the second happened as rescuers rushed to help those injured in the first explosion.
Pakistan Army contingents and FC personnel reached the site of the attack to aid in rescue efforts. Abdul Razzaq Cheema, director general of police in Baluchistan province, of which Quetta is capital, told Reuters the bomber had detonated a vehicle packed with explosives.
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A senior government official Wazir Khan Wazir told Reuters that the blasts took place at a market within three minutes of each another.
"Two Army aviation helicopters have taken off from Peshawar to Parachinar for the speedy evacuation of the injured to Peshawar", a statement issued by the military's media wing said. At least ten people are reported to be killed and over fifty are reported to be injured in the explosion. The rescue operation is in progress.
In January, 25 people were killed and 87 others when a bomb tore through a crowded vegetable market in the same city. The incident occurred near Inspector General of Police Ehsan Mehboob's office on Gulistan Road area of the provincial capital, Quetta.
Of the injured, nine are said to be policemen. At least 13 bodies were taken to hospital, along with 19 wounded people, said Wasim Baig, a spokesman for the Civil Hospital in Quetta.