The season opener for City will be on the road to newly promoted Brighton & Hove Albion, who will certainly make the Amex Stadium a insane atmosphere for the team's first ever Premier League match.
The 2017/18 Premier League fixtures have been announced, but which of the leading title contenders has the toughest finish to the season?
But it could prove a tricky opening few weeks for the defending champions too, with Chelsea hosting Everton (26 August), visiting 2015-16 winners Leicester after the worldwide break and then welcoming Arsenal (16 September).
The fans group raises the point that for fans of outer clubs such as Southampton, Brighton, Newcastle and Burnley among others, having to pay for five road league matches as well as all the transportation involved.
Anti-Sharia rallies this weekend worry Muslim leaders
What a powerful message that would be, even if it's not precisely the message rabble-rousers on both sides might wish to convey. These rallies are not against Sharia; they are rallies against the Muslim community.
Everton supporters have taken to social media to react to their confirmed fixture list - a fixture list that has left fans distraught.
Bookies reacted to the fixtures publication with William Hill making Chelsea 3/1 second favourites to retain their title, with Manchester City 2/1 favourites.
Championship play-off winners Huddersfield Town, back in the top-flight of English football for the first time since 1972, head south to Selhurst Park to battle Crystal Palace.
Tottenham will play their home games at the national stadium for the 2017-18 season while construction work on their new ground takes place. It'll be the first time West Ham have played at home on the final day since they played Reading in 2013.
Spurs, who have moved out of White Lane while their new stadium is being built, face the champions Chelsea at their temporary home on the second weekend of the campaign. David Wagner's Terriers face Chelsea, Everton, Manchester City and Arsenal in their final four games. Instead, they will face champions Chelsea in their first home game - a repeat of April's FA Cup semifinal, which Spurs somehow lost 4-2.
The game at the Olympic Stadium will be followed by a Champions League group match for Spurs but there is next to no chance that Pochettino will rest players for the trip across London.