"This reminds me very much of the events of 2003, when U.S. representatives in the Security Council showed alleged chemical weapons discovered in Iraq", Putin said, bringing back the spectre of a war started on lies, whose result is a disintegrating, destroyed Iraq.
Despite hopes of an improvement in ties under Trump, the Tillerson-Lavrov talks look set to be dominated by the war of words over Syria - where more than 320,000 people have died in six years of brutal war.
Details of the meeting were not released.
Despite the dreary outlook, Trump said that he heard that Secretary of State Rex Tillerson had a positive meeting with Russian officials.
As Tillerson sat down for talks with his Russian counterpart Sergei Lavrov on Wednesday, a senior Russian official assailed the "primitiveness and loutishness" of U.S. rhetoric, part of a volley of statements that appeared timed to maximize the awkwardness during the first visit to Moscow by a member of Trump's cabinet.
Where relations between the two countries go from this point on is hard to guess.
"The world's two foremost nuclear powers can not have this kind of relationship", he said.
The meetings come on the heels of a US missile strike on an air base in Syria in retaliation for a chemical weapon attack on civilians that's been blamed on the Bashar al-Assad regime.
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Can Russia abandon Assad?
Mr Lavrov said on Wednesday Russia had lots of questions about the "very ambiguous" and "contradictory" ideas coming from the US.
"It'd be a fantastic thing if we got along with Putin and if we got along with Russian Federation".
Lavrov says Russian Federation thinks there is no need for a U.N. Security Council resolution on the attack until the U.N. chemical weapons watchdog has completed an objective probe. This team has already found Syrian government forces were responsible for three chlorine gas attacks in 2014 and 2015 and that Islamic State militants used mustard gas.
Boris Johnson has urged Russian Federation to stop "acting as a lifeline for Assad's murderous regime" in Syria and instead to "live up to its responsibilities as a global power".
"We are mindful of seriousness of that particular interference in our elections and i'm sure Russian Federation is mindful of it as well". "That's exactly what is happening now..."
"It's deplorable, and we regret what is going on, but we can do little except asking to back accusations with facts", Mr Lavrov said.
"That's a butcher. That's a butcher", Trump said of Assad.