Lloyd has 96 goals in 232 worldwide appearances with the national team.
USA women's national team co-captain Carli Lloyd is set to join Manchester City, and her signing could be announced as soon as Wednesday, according to sources with knowledge of the deal. It is believed that once her deal ends with Manchester City she will return to the NWSL and play for the Houston Dash for the remainder of their season.
While such a move isn't unusual on the men's side of soccer, it hasn't been the norm for women.
"Carli and I spoke this weekend and she informed me of an opportunity to play for Manchester City as they chase a Champions League trophy".
Preparing for a new challenge at Manchester City, FIFA player of the year Carli Lloyd is relishing the chance to improve her game.
The Nigeria worldwide - one of the stars of the 2015 Women's World Cup in Canada - spent two years in England, joining Arsenal from Liverpool at the beginning of 2016. Retired national team midfielder Heather O'Reilly is playing for Arsenal.
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The relentless drive and determination of the two-time FIFA Player of the Year won't allow that to happen.
"Carli has had an incredible career and is recognized as one of the best in the world", coach Nick Cushing said.
City were crowned champions of the Super League last season after going the entire season unbeaten.
Press Association Sport understands an announcement is likely to come on Wednesday, with the United States attacking midfielder joining the English champions on a short-term basis from the Houston Dash. "I'm disappointed that she will not be with the team as we start the season, but I wished her all the best with her decision". "We are all looking forward to working with her over the coming months".
Before Lloyd takes the pitch for Manchester City, the Delran native will appear locally with the USWNT in the SheBelieves Cup against Germany on March 1 at Talen Energy Field in Chester, Pennsylvania.