Harlequins openside flanker Clifford has come into the back-row in place of Tom Wood, who drops to the replacements, while Exeter wing Jack Nowell replaces Jonny May, who also drops to the bench.
Biggar and North's availability means Wales are unchanged behind the scrum, with Sam Davies having to wait for his first Test start following his impressive appearance from the bench in Rome.
A video ahead of this weekend's rugby game asked "What's good about England?" and featured a series of Wales fans with blank expressions apparently unable to answer the question.
"I've done one every week we've had a home game, I'm doing a Le Mans vehicle this week".
"These are the games you want to be part of as a player and a coach. That's when we'll decide what is our best 23". Some of our players have never played at Principality Stadium.
Mike Brown, Jack Nowell and Elliot Daly are the trio selected by Jones so size is certainly on Wales' side.
Despite their own good form, back row Sam Warburton is very wary of the threat England pose, even going so far as to compare England with the imperious All Blacks.
"Playing Wales in Cardiff is one of the biggest games in world rugby and we're excited", he said.
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He was averaging a career high in points per game with 20.1, in rebounds with 6.2, and assists with 2.8 per game. David Altchek, the team physician for the New York Mets, performed the first ACL surgery on Parker.
Jones and the 22-year-old have been tipped in many quarters as the British and Irish Lions' prospective Test second-row pairing in New Zealand later this year, and although Itoje is now featuring at blindside flanker for England, his impact remains a considerable one.
He said: "We are fortunate to have a stadium that adds to the occasion".
"The Italians are ever improving, so we are expecting another tough encounter, particularly up front, where they made life hard for Wales last week".
"He's the most positive person I've ever met and he's a great guy for them". "That is the biggest bonus they are going to get moving forwards, as Eddie has alluded to".
15 games unbeaten and Grand Slam champions - have not lost to Wales in the RBS 6 Nations in four years. "We are anxious about both of them". We've trained as best as we can and looking forward to one of the best sides if not the best side in the northern hemisphere at the moment.
"Those things happen regularly in those sorts of countries, so the challenge for a team to play away is to be better than that".
"We've got a few options".
Coach Eddie Jones picked Maro Itoje, Jack Clifford and Nathan Hughes as the loose-forward trio, who have made just four worldwide starts in the back row.